Protein kinase A (PKA) is activated by cAMP in the cells, which phosphorylates specific proteins (PProteins). When ACTH binds to plasma membrane receptors, stimulatory G proteins connect those receptors to adenylyl cyclase (AC) (Gs). ĪCTH’s primary effects on steroidogenesis.
Īngiotensin II increases cytosolic calcium and activates protein kinase C in the cells of the zonaglomerulosa to stimulate aldosterone synthesis.
On these cells, ACTH also has a trophic effect. 3.9 Control over the production of adrenal steroidsīy increasing intracellular cAMP, ACTH increases glucocorticoid and androgen synthesis in the zonafasciculata and zonareticularis of the adrenal cortex (cAMPactivates protein kinase A, which phosphorylates proteins that regulate steroidogenesis).
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